Overview
Opioids assist folks discover reduction from ache, whether or not attributable to surgical procedure or from a persistent situation, however they’ve the potential to be abused or result in harmful illicit medicine. This has created a disaster that has a major influence on our world society. A 2015 report from the White Home Council of Financial Advisers estimated that the opioid disaster price the U.S. financial system over US$500 billion. The disaster has gotten worse. A latest 500-page congressional report estimated that opioid-related deaths now price US$1 trillion yearly, roughly 4.3 p.c of the nation’s GDP. A complementary report from the U.S. Heart for Illness Prevention (CDC) consists of nonfatal accidents and estimates the price to be US$4.2 trillion. Trying past the US, the World Well being Group estimates that 500,000 folks die per 12 months attributable to drug overdose, and 70 p.c of these deaths are attributable to opioids.
What could be executed to fight the opioid disaster? It’s a posh downside, with governments, researchers, and docs all looking for the reply. Remedy is one reply to combatting this disaster, ideally serving to opioid addicts return to a life that’s free from drug abuse. But remedy for opioid dependancy sometimes consists of cleansing, psychotherapy and changing the issue opioid with a weaker opioid, similar to methadone or buprenorphine. Whereas this routine could assist some customers get well, one research discovered that 91 p.c of addicts will relapse after remedy. We want more practical remedy to actually fight the disaster.
Psychedelics have emerged as a promising remedy for opioid dependancy, together with displaying potential for treating alcohol use dysfunction and even despair. Ketamine, recognized for its position in anesthesia, could also be an efficient remedy for alcohol use dysfunction. Psilocybin, the energetic ingredient in psychedelic mushrooms, exhibits promise for treating despair. Ibogaine, which is discovered primarily within the roots of the Iboga plant, could assist opioid addicts get well from their dependancy and supply a non-opioid alternative for ache reduction. Nonetheless, every psychedelic wants additional analysis and improvement to turn into a very therapeutic remedy that may be legally utilized in remedy.
Nirvana Life Sciences (CSE:NIRV) was based to develop novel therapeutic merchandise derived from psychedelics. The corporate believes that naturally sourced psychedelics utilized in distinctive formulations can ship non-addictive options that help in opioid dependancy remedy and ongoing ache administration. Nirvana Life Sciences is concentrated strictly on growing efficient merchandise, fairly than providing wellness retreats or clinics like a few of their opponents.
The corporate has focused two merchandise for its first improvement part. One product will deal with transitioning from opioids to non-addictive ache reduction therapies and ideally prevents relapse. The second product will present non-addictive ache reduction. Nirvana Life Sciences started by buying the mental property (IP) behind these formulations and has since carried out its personal analysis to advance them.
How is the corporate doing this legally? Using psychedelics in customary medicinal therapies is a brand new frontier, and as such, Nirvana Life Sciences is taking each precaution towards authorized issues and even contemplating the curiosity criminals could have in its amenities. It has acquired a Part 56 Exemption from Well being Canada, enabling them to legally conduct its analysis and improvement in Vancouver. Moreover, its new facility shall be constructed to Stage 9 Safety Requirements to safeguard its analysis. The corporate can be pursuing a Seller’s License from Well being Canada to permit for the motion of supplies between licensees. The tip objective is to introduce FDA-approved drugs for widespread utilization.
Pre-clinical analysis for its formulations have already begun. This analysis is being undertaken on the College of Camerino in Italy. This lab was granted particular permission from the Italian authorities to work with psilocybin-based compounds. Experiences from these trials are anticipated in Q3 2022.
Nirvana Life Sciences is led by visionaries and docs working collectively to totally develop these doubtlessly revolutionary drugs. Bruce Clark, CEO, is motivated by discovering new options to advanced societal points and has 30 years of expertise managing revolutionary corporations. Dr. Sazzad Hossain, CSO, has served on main Canadian bio pharmaceutical corporations and is taken into account a drug discovery chief. Robert August, head of innovation, is an academically skilled chemist who’s revered within the psychedelic group and is a robust advocate for ending prohibition.
Michael McCune, Vice President of Operations, has years of expertise within the extraction house.. Connie Dangle, CFO, has over 20 years of expertise in accounting and administration, together with working with international and home corporations. The corporate has attracted a powerful crew of researchers together with Dr. Massimo Nabissi and Dr. Naseem Gaur.
Firm Highlights
- Nirvana Life Sciences is an revolutionary analysis and improvement firm centered on novel formulations for opioid dependancy and ache administration that use psychedelic compounds.
- The corporate is solely centered on merchandise, fairly than wellness retreats or psychotherapy packages like a few of its opponents.
- Nirvana Life Sciences’ first part of improvement is concentrating on two merchandise, one to assist in opioid dependancy restoration and the opposite is concentrating on non-addictive ache administration.
- IP has been bought from researchers who’ve extensively studied the consequences of psychedelic compounds for medicinal functions
- The corporate is taking each precaution to function legally and defend towards potential prison parts which will goal its amenities
- Pre-clinical analysis started in 2021 and the outcomes are anticipated in Q3 2022 and can decide future developments
- A robust crew of docs and visionaries lead the corporate, every bringing their specialty to the corporate to totally develop its merchandise
Key Merchandise
Remedy for Opioid Habit
The corporate has formulated a product that assists within the transition from opioids to non-addictive ache reduction. A lot of Nirvana Life Sciences’ focus is on growing and refining this product, because it paves the way in which for its second product which might function a standalone product for these hooked on opioids to return to an opioid-free life.
Mission Highlights:
- Formulated to Stop Abuse: The energetic ingredient can solely be launched when taken orally, making IV or insufflation ineffective because the energetic ingredient won’t be launched.
- Prioritizing Pure Supplies Over Artificial Replacements: Most opponents purpose to develop artificial psychedelics, whereas Nirvana Life Sciences is concentrated on perfecting a scalable course of that extracts the specified compounds from pure sources, similar to mushrooms. The corporate should still use artificial alternate options if required.
- Unique License to Proprietary Extraction Expertise: The corporate has secured a license that provides it unique entry to extraction expertise that may assist scale the manufacturing of its drugs, referred to as PureAI Distillation.
Remedy for Non-Addictive Ache Administration
Many individuals who develop opioid dependancy nonetheless want ache administration therapies. The corporate’s second product goals to offer ache reduction with out creating a brand new dependancy. Psychedelic compounds have inherent ache reduction properties which were remoted to be used because the energetic ingredient on this product.
Mission Highlights:
- Solely Efficient Orally: Similar to the dependancy remedy product, the corporate’s ache administration remedy will solely be efficient when taken orally.
- Artificial Extraction Could Show Viable: The contracted analysis facility in New Delhi has undertaken a novel course of for producing artificial psilocybin supplies at scale.
- Presently Present process Preclinical Analysis: The corporate’s formulations are present process pre-clinical analysis with outcomes anticipated in Q3 2022.
Administration Group
Bruce Clark – Chief Government Officer
Bruce Clark leads the Nirvana crew, looking for new options to one among our society’s most confounding points. He sees nice potential within the alternatives for the event of latest approaches to a posh downside that’s each a public well being and financial difficulty for our communities. Clark is a confirmed innovator who brings 30 years of administration expertise throughout quite a lot of industries, together with vitality, meals and beverage manufacturing and life science. He possesses broad expertise in product improvement, manufacturing and product distribution and a transparent understanding of the regulatory course of. He has a deep understanding of the general public coverage points at play and the significance of collaboration with all ranges of presidency and well being professionals via the event course of.
Connie Dangle – Chief Monetary Officer
Connie Dangle has over 20 years of finance, accounting, and administration expertise in quite a lot of industries, together with vitality, mining, and well being science. Prior to now 12 years, Dangle has acted as an advisor, officer and director for numerous private and non-private corporations, which embody Canadian-based corporations to foreign-controlled entities. From 1999 to 2009, Dangle labored in skilled accounting companies and held senior positions in tax and audit practices. Having served over 40 public- and private-companies, she has gained in-depth information of economic and regulatory affairs. Dangle’s expertise in coping with folks from totally different cultures and disciplines has solidified her capability to know the wants of stakeholders and talk advanced concepts. Dangle is a Member of the Chartered Skilled Accountants of Canada and British Columbia and holds a bachelor of accounting science from the College of Calgary.
Dr. Sazzad Hossain – Chief Scientific Officer
Dr. Sazzad Hossain is the previous chief scientific officer of InMed Prescription drugs, a number one public Canadian biopharmaceutical firm. Beforehand he labored as a senior scientist on the Biotechnology Analysis Institute of Nationwide Analysis Council Canada. Dr. Hossain is a drug discovery chief with over 15 years of biotech and pharmaceutical expertise with small molecules and biologics in a number of illness indications. He has expertise in accelerated drug discovery and commercialization processes with mixed expertise in preclinical in vivo pharmacology, drug metabolism and pharmacokinetics (DMPK), security and toxicology. He has led groups within the strategic design of latest pure well being merchandise and generated a whole lot of thousands and thousands of {dollars} in income by main the event of a number of profitable compounds. Dr. Hossain holds a PhD in biology and was a postdoctoral fellow on the Centre for Molecular Medicines and Therapeutics on the College of BC.
Robert August – Head of Innovation
Robert August holds a grasp’s of science diploma and is an academically skilled medicinal chemist with a deal with ergolines, phenethylamines and tryptamines. August started his tutorial profession at Loyola College in Baltimore, Maryland. Throughout his undergraduate years, he labored as an analytical chemist for Martel Laboratories the place he acquired his state analytical certifications for elevated intracranial strain (ICP), gasoline chromatography–mass spectrometry (GCMS) and liquid chromatography with tandem mass spectrometry (LCMS) operations.
Whereas pursuing a postgraduate diploma in medicinal chemistry at Johns Hopkins College, he turned his focus towards the synthesis of psychoactive and psychedelic compounds, specifically ergolines similar to LSD and phenethylamines like MDMA and 2CB. Round this time, August started to work as a analysis chemist; and, finally, started to actively pursue working partnerships with different chemists who have been researching psychedelic compounds like Dr. David E. Nichols and Nick Sand, with whom August labored briefly in Vancouver, BC. After incomes a repute as a talented chemist, he was invited to work alongside Ben Alkire at Purdue College in Lafayette, Indiana, the place he went on to cofound Berkeley-Clearlight Analysis (BCRG). Whereas forming BCRG, August acquired limitless entry to the D.E. Nichols Archive at Purdue College and the huge array of synthesis notes created by Dr. Oberlender throughout his time as a chemist for the Nichols’ crew. Within the years that adopted, August synthesized quite a few novel compounds and analysis chemical compounds, turning into the primary particular person to synthesize 3,4-MDMA Monohydrate HCl as a crystalline stable and as a beta ketone. August is a extremely revered member of the psychedelic group and an advocate for ending prohibition.
Michael McCune – Vice President Operations
Michael McCune is a seasoned entrepreneur and innovator within the extraction house. Since 2013, he has utilized his ardour for science to growing novel processes for producing energetic pharmaceutical elements (API) for the hashish business. He has constructed a specialty for at-scale extraction of all kinds of supplies. McCune led the event of a modern distillation system that provides vital operational benefits and automation. He has overseen the event, trials and contract manufacture of this technique. McCune is acknowledged as a pacesetter in these applied sciences and has co-authored a number of patents. He maintains a worldwide community and has offered at quite a few conferences on the subjects of extraction and hashish applied sciences.
